Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 20/20 | 0.51 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | RPTOR | Q8N122 | 4/20 | 0.44 |
| ▸ | MLST8 | Q9BVC4 | 4/20 | 0.44 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.43 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL441912 | 0.90 | MTOR (0.54) | MTORPIK3R1PIK3CACYP3A4KCNH2 | |
| SCHEMBL441730 | 0.90 | MTOR (0.60) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL413022 | 0.90 | MTOR (0.60) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL412634 | 0.88 | MTOR (0.53) | MTORPIK3R1PIK3CACYP3A4KCNH2 | |
| SCHEMBL443859 | 0.82 | MTOR (0.60) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL443858 | 0.82 | MTOR (0.60) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL444727 | 0.82 | MTOR (0.68) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL443627 | 0.80 | MTOR (0.58) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL442411 | 0.80 | MTOR (0.71) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL442412 | 0.80 | MTOR (0.71) | MTORPIK3CACYP3A4KCNH2RPTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140296234-A1 | PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | CELLZOME LIMITED | 2014-10-02 | — | — | US | disclosed |
| US-20140296234-A1 | PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | CELLZOME LIMITED | 2014-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296234-A1 | PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | MTOR, RICTOR, RPTOR | MTOR 1/4885PIK3R1 118/4885PIK3CA 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.