Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.50 |
| ▸ | MEN1 | O00255 | 6/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | FES | P07332 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RPS27 | P42677 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16264714 | 0.86 | MEN1 (0.56) | KMT2AMEN1POLBCTDSP1GAA | |
| SCHEMBL31155156 | 0.80 | MAPT (0.48) | KMT2AMEN1GAAMAPTSMN1; SMN2 | |
| SCHEMBL9208078 | 0.80 | GAA (0.52) | KMT2APOLBGAAMAPTSMN1; SMN2 | |
| SCHEMBL8592976 | 0.76 | MAPT (0.43) | KMT2AMEN1POLBGAAMAPT | |
| SCHEMBL19956899 | 0.75 | MEN1 (0.63) | KMT2AMEN1POLBCTDSP1GAA | |
| SCHEMBL25025146 | 0.73 | POLB (0.41) | POLBGAAMAPTSMN1; SMN2 | |
| SCHEMBL31163657 | 0.73 | POLB (0.41) | POLBGAAMAPTSMN1; SMN2 | |
| SCHEMBL22301648 | 0.73 | POLB (0.41) | POLBGAAMAPTSMN1; SMN2 | |
| SCHEMBL14546802 | 0.72 | GAA (0.45) | POLBGAAMAPTMAPK1KDM4E | |
| SCHEMBL31225285 | 0.71 | GAA (0.42) | POLBGAAMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014160200-A9 | RAS INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2014-11-27 | — | — | WO | disclosed |
| WO-2014160200-A1 | RAS INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2014-10-02 | — | — | WO | disclosed |