Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA known ✓ | P35790 | 12/20 | 0.63 |
| ▸ | KDM4A | O75164 | 3/20 | 0.71 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | APP | P05067 | 1/20 | 0.55 |
| ▸ | CHKB | Q9Y259 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL16147952 | 1.00 | KDM4A (0.71) | KDM4AKDM2ACHKAALDH1A1LMNA | |
| Bromide SCHEMBL16148713 | 0.98 | KDM4A (0.69) | KDM4AKDM2ACHKAALDH1A1LMNA | |
| Bromide SCHEMBL16148716 | 0.98 | KDM4A (0.69) | KDM4AKDM2ACHKAALDH1A1LMNA | |
| SCHEMBL17975342 | 0.98 | KDM4A (0.73) | KDM4AKDM2ACHKAALDH1A1LMNA | |
| SCHEMBL17975337 | 0.97 | KDM4A (0.71) | KDM4AKDM2ACHKAALDH1A1LMNA | |
| Bromide SCHEMBL17961956 | 0.94 | CHKA (0.68) | KDM4AKDM2ACHKAALDH1A1LMNA | |
| Bromide SCHEMBL17961946 | 0.94 | CHKA (0.68) | KDM4AKDM2ACHKAALDH1A1LMNA | |
| Bromide SCHEMBL17961945 | 0.94 | CHKA (0.68) | KDM4AKDM2ACHKAALDH1A1LMNA | |
| Bromide SCHEMBL17961991 | 0.94 | CHKA (0.68) | KDM4AKDM2ACHKAALDH1A1LMNA | |
| SCHEMBL17971162 | 0.92 | KDM4A (0.68) | KDM4AKDM2ACHKAALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240299589-A1 | DIAGNOSING AND TREATING CANCER | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2024-09-12 | — | — | US | disclosed |
| US-11813338-B2 | Diagnosing and treating cancer | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2023-11-14 | — | — | US | disclosed |
| US-20160220703-A1 | DIAGNOSING AND TREATING CANCER | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2016-08-04 | — | — | US | disclosed |
| WO-2014165216-A1 | DIAGNOSING AND TREATING CANCER | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2014-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160220703-A1 | DIAGNOSING AND TREATING CANCER | CHKA, CHKB, CILK1 | CHKA 1/4885KDM4A 1365/4885KDM2A 1664/4885 |
| US-20240299589-A1 | DIAGNOSING AND TREATING CANCER | CHKA, CHKB, CILK1 | CHKA 1/4885KDM4A 1365/4885KDM2A 1664/4885 |
| US-11813338-B2 | Diagnosing and treating cancer | CHKA, CHKB, CILK1 | CHKA 1/4885KDM4A 1365/4885KDM2A 1664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.