Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A5 | Q15758 | 2/20 | 0.58 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.55 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.50 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.49 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.49 |
| ▸ | KIF11 | P52732 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22444600 | 1.00 | SLC1A5 (0.58) | SLC1A5TAAR1MTNR1AMTNR1BCYP1A2 | |
| SCHEMBL16147990 | 1.00 | SLC1A5 (0.58) | SLC1A5TAAR1MTNR1AMTNR1BCYP1A2 | |
| SCHEMBL28741577 | 0.87 | TAAR1 (0.54) | TAAR1MTNR1AMTNR1BHDAC1HDAC6 | |
| SCHEMBL146611 | 0.85 | TAAR1 (0.66) | TAAR1CYP1A2 | |
| SCHEMBL29855157 | 0.85 | TAAR1 (0.66) | TAAR1CYP1A2 | |
| SCHEMBL146610 | 0.85 | TAAR1 (0.66) | TAAR1CYP1A2 | |
| SCHEMBL4596077 | 0.85 | TAAR1 (0.66) | TAAR1CYP1A2 | |
| SCHEMBL15802563 | 0.84 | CYP1A2 (0.58) | CYP1A2GRIK1GRIK2KIF11 | |
| SCHEMBL17194111 | 0.84 | CYP1A2 (0.58) | CYP1A2GRIK1GRIK2KIF11 | |
| SCHEMBL24440174 | 0.84 | TAAR1 (0.53) | TAAR1MTNR1AMTNR1BCYP1A2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10344060-B2 | Potent and selective inhibitors of Nav1.7 | AMGEN INC. (US) | 2019-07-09 | — | — | US | disclosed |
| EP-2970408-B1 | POTENT AND SELECTIVE INHIBITORS OF NAV1.7 | AMGEN INC (US) | 2018-01-10 | — | — | EP | disclosed |
| US-20160024159-A1 | POTENT AND SELECTIVE INHIBITORS OF NAV1.7 | AMGEN INC. (US) | 2016-01-28 | — | — | US | disclosed |
| EP-2970408-A2 | POTENT AND SELECTIVE INHIBITORS OF Nav1.7 | Amgen Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014165277-A2 | POTENT AND SELECTIVE INHIBITORS OF Nav1.7 | AMGEN INC. (US) | 2014-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10344060-B2 | Potent and selective inhibitors of Nav1.7 | SCN7A, SCN9A, SCN1A | SLC1A5 1893/4885TAAR1 2165/4885MTNR1A 1300/4885 |
| US-20160024159-A1 | POTENT AND SELECTIVE INHIBITORS OF NAV1.7 | SCN7A, SCN9A, SCN1A | SLC1A5 1893/4885TAAR1 2165/4885MTNR1A 1300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.