Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 17/20 | 0.71 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.60 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.53 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4862221 | 0.92 | MAP2K1 (0.73) | MAP2K1MAP2K2CYP2C9MAP2K5EIF2AK1 | |
| SCHEMBL4851729 | 0.91 | MAP2K1 (0.60) | MAP2K1MAP2K2PIM1CAMK2BMAP2K5 | |
| SCHEMBL4863428 | 0.90 | MAP2K1 (0.72) | MAP2K1MAP2K2HDAC3HDAC4HDAC1 | |
| SCHEMBL4853157 | 0.88 | MAP2K1 (0.60) | MAP2K1MAP2K2PIM1CAMK2BMAP2K5 | |
| SCHEMBL7050589 | 0.88 | MAP2K1 (0.69) | MAP2K1MAP2K2CYP2C9MAP2K5EIF2AK1 | |
| SCHEMBL4863390 | 0.88 | MAP2K1 (0.60) | MAP2K1MAP2K2PIM1CAMK2BMAP2K5 | |
| SCHEMBL4857304 | 0.87 | MAP2K1 (0.56) | MAP2K1MAP2K2PIM1CAMK2BMAP2K5 | |
| SCHEMBL4860624 | 0.87 | MAP2K1 (0.59) | MAP2K1MAP2K2PIM1CAMK2BMAP2K5 | |
| SCHEMBL4852751 | 0.87 | MAP2K1 (0.56) | MAP2K1MAP2K2PIM1CAMK2BCYP2C9 | |
| SCHEMBL4859616 | 0.86 | MAP2K1 (0.58) | MAP2K1MAP2K2PIM1CAMK2BHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9611258-B2 | Dual MEK/PI3K inhibitors and therapeutic methods using the same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2017-04-04 | — | — | US | disclosed |
| US-20160002212-A1 | DUAL MEK/PI3K INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2016-01-07 | — | — | US | disclosed |
| WO-2014164942-A1 | DUAL MEK/PI3K INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160002212-A1 | DUAL MEK/PI3K INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | MAP2K2, MAP2K1, MAP2K7 | MAP2K1 2/4885MAP2K2 1/4885PIM1 220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.