SCHEMBL16159256

SCHEMBL16159256

C1=COC(c2cccc(-c3c4ccccc4c(-c4cccc(-c5ncco5)n4)c4ccc(-c5ccc(-c6cccc7ccccc67)cc5)cc34)n2)N1

nearest known ligand 0.32

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ENPP1 P22413 2/20 0.32
ENPP3 O14638 1/20 0.32
MCL1 Q07820 1/20 0.32
ALK Q9UM73 1/20 0.32
KDM4E B2RXH2 1/20 0.32
NPC1 O15118 1/20 0.32
ALDH1A1 P00352 1/20 0.32
TP53 P04637 1/20 0.32
MAPT P10636 1/20 0.32
HPGD P15428 1/20 0.32
MAPK1 P28482 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
HSD17B10 Q99714 1/20 0.32
CCNT1 O60563 1/20 0.31
CCNA2 P20248 1/20 0.31
CDK2 P24941 1/20 0.31
CDK9 P50750 1/20 0.31
CA12 O43570 1/20 0.30
CA1 P00915 1/20 0.30
CA2 P00918 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16159734 0.92 MCL1 (0.38) MCL1
SCHEMBL16159190 0.92 MCL1 (0.38) MCL1
SCHEMBL16159713 0.91 MCL1 (0.33) MCL1HPGD
SCHEMBL16159217 0.91 MCL1 (0.37) MCL1
SCHEMBL16159719 0.90 KDM4E (0.33) MCL1KDM4EALDH1A1TP53MAPT
SCHEMBL16159191 0.90 MCL1 (0.37) MCL1
SCHEMBL17704343 0.87 ENPP1 (0.41) ENPP1ENPP3MCL1ALKKDM4E
SCHEMBL16159238 0.86 CCNT1 (0.32) ENPP1ENPP3MCL1ALKKDM4E
SCHEMBL16159672 0.86 BRD4 (0.31)
SCHEMBL16159485 0.84 ENPP1 (0.31) ENPP1ENPP3ALKKDM4ENPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014163173-A1 ELECTRON TRANSPORT MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME JNC株式会社 (JP) 2014-10-09 WO disclosed