Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 5/20 | 0.66 |
| ▸ | KDR | P35968 | 6/20 | 0.46 |
| ▸ | KIT | P10721 | 4/20 | 0.46 |
| ▸ | FLT3 | P36888 | 3/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | PRKDC | P78527 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.38 |
| ▸ | RELA | Q04206 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8402297 | 0.92 | BTK (0.72) | BTKKDRKITFLT3PIK3CD | |
| SCHEMBL8402292 | 0.85 | BTK (0.80) | BTKKDRKITFLT3MAP4K4 | |
| SCHEMBL6116183 | 0.85 | BTK (0.73) | BTKKDRKITFLT3GAA | |
| SCHEMBL6115528 | 0.83 | BTK (0.72) | BTKKDRKITFLT3PIK3CD | |
| SCHEMBL8402340 | 0.82 | BTK (0.66) | BTKKDRKITFLT3PIK3CD | |
| SCHEMBL6115834 | 0.81 | BTK (0.74) | BTKKDRKITFLT3PIK3CD | |
| SCHEMBL8402304 | 0.80 | BTK (0.74) | BTKKDRKITFLT3PIK3CD | |
| SCHEMBL1163758 | 0.80 | BTK (1.00) | BTKKDRKITFLT3KMT2A | |
| SCHEMBL8402320 | 0.79 | BTK (0.83) | BTKKDRKITFLT3PIK3CD | |
| SCHEMBL6115729 | 0.79 | BTK (0.69) | BTKKDRKITFLT3PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-A1 | Azaindazoles as Btk kinase modulators and use thereof | Bristol-Myers Squibb Company (US) | 2014-10-15 | — | — | EP | claimed |