Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.40 |
| ▸ | CCR9 | P51686 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16162081 | 0.93 | CCR9 (0.39) | BRAFCYP2C9CCR9 | |
| SCHEMBL16162085 | 0.88 | CYP2C19 (0.44) | BRAFCYP2C9CYP2C19CYP3A4CCR9 | |
| SCHEMBL16162040 | 0.88 | KIT (0.40) | BRAFCYP2C9CYP2C19CCR9 | |
| SCHEMBL16162153 | 0.87 | BRAF (0.44) | BRAFCYP2C9CYP2D6CYP2C19CYP3A4 | |
| SCHEMBL16162111 | 0.86 | CYP3A4 (0.46) | BRAFCYP2C9CYP2C19CYP3A4 | |
| SCHEMBL16162106 | 0.86 | CYP3A4 (0.47) | BRAFCYP2C9CYP2C19CYP3A4 | |
| SCHEMBL300408 | 0.85 | BRAF (0.46) | BRAFCYP2C9CYP2D6CYP2C19CYP3A4 | |
| SCHEMBL16162083 | 0.85 | BRAF (0.43) | BRAFCYP2C9CYP3A4 | |
| SCHEMBL16162113 | 0.85 | BRAF (0.48) | BRAFCYP2C9CYP3A4 | |
| SCHEMBL16162151 | 0.84 | CYP2D6 (0.43) | BRAFCYP2C9CYP2D6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170830-B1 | 2-FLUORO-BENZENESULFONAMIDE COMPOUNDS AS Raf KINASE MODULATORS | PLEXXIKON INC (US) | 2014-10-15 | — | — | EP | claimed |