SCHEMBL16161990

SCHEMBL16161990

CC1(C)CC(=O)c2c(C(F)(F)F)nn(-c3ccc(C(N)=O)c(NC(CO)(CO)CCC(=O)O)c3)c2C1

nearest known ligand 0.64

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 17/20 0.64
HSP90AB1 P08238 15/20 0.64
HSP90B1 P14625 5/20 0.64
TRAP1 Q12931 5/20 0.64
OPRM1 P35372 1/20 0.43
HDAC4 P56524 1/20 0.40
HDAC1 Q13547 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
HDAC9 Q9UKV0 1/20 0.40
HDAC5 Q9UQL6 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1219910 0.93 HSP90AA1 (0.70) HSP90AA1HSP90AB1HSP90B1TRAP1OPRM1
SCHEMBL1219602 0.88 HSP90AA1 (0.68) HSP90AA1HSP90AB1HSP90B1TRAP1OPRM1
SCHEMBL16161811 0.88 HSP90AA1 (0.60) HSP90AA1HSP90AB1HSP90B1TRAP1OPRM1
SCHEMBL16161812 0.87 HSP90AA1 (0.63) HSP90AA1HSP90AB1HSP90B1TRAP1OPRM1
SCHEMBL1747254 0.87 HSP90AA1 (0.63) HSP90AA1HSP90AB1HSP90B1TRAP1OPRM1
SCHEMBL19086236 0.84 HSP90AA1 (0.65) HSP90AA1HSP90AB1HSP90B1TRAP1OPRM1
SCHEMBL3629714 0.83 HSP90AA1 (0.70) HSP90AA1HSP90AB1HSP90B1TRAP1OPRM1
SCHEMBL8139903 0.82 HSP90AA1 (0.68) HSP90AA1HSP90AB1HSP90B1TRAP1OPRM1
SCHEMBL3630905 0.82 HSP90AA1 (0.68) HSP90AA1HSP90AB1HSP90B1TRAP1OPRM1
SCHEMBL8133920 0.82 HSP90AA1 (0.68) HSP90AA1HSP90AB1HSP90B1TRAP1OPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2380879-B1 Tetrahydroindolone and tetrahydroindazolone derivatives ESANEX INC (US) 2017-07-12 EP claimed
EP-1856057-B1 TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES SERENEX INC (US) 2014-10-15 EP claimed