Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 20/20 | 0.78 |
| ▸ | AURKA | O14965 | 19/20 | 0.78 |
| ▸ | AURKB | Q96GD4 | 9/20 | 0.64 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL665273 | 0.87 | RPS6KB1 (1.00) | RPS6KB1AURKAAURKBPDPK1 | |
| SCHEMBL665613 | 0.78 | RPS6KB1 (1.00) | RPS6KB1AURKAAURKBPDPK1 | |
| SCHEMBL666995 | 0.77 | AURKA (1.00) | RPS6KB1AURKAAURKB | |
| SCHEMBL666227 | 0.76 | RPS6KB1 (1.00) | RPS6KB1AURKAAURKBPDPK1 | |
| SCHEMBL665620 | 0.75 | RPS6KB1 (1.00) | RPS6KB1AURKAAURKBPDPK1 | |
| SCHEMBL13256617 | 0.75 | RPS6KB1 (0.82) | RPS6KB1AURKAAURKBPDPK1 | |
| SCHEMBL666965 | 0.75 | RPS6KB1 (1.00) | RPS6KB1AURKAAURKBPDPK1 | |
| SCHEMBL666078 | 0.75 | RPS6KB1 (1.00) | RPS6KB1AURKAAURKBPDPK1 | |
| SCHEMBL666349 | 0.74 | AURKA (1.00) | RPS6KB1AURKAAURKB | |
| SCHEMBL22300459 | 0.74 | PDE5A (0.60) | RPS6KB1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396307-B1 | NOVEL AMINO AZAHETEROCYCLIC CARBOXAMIDES | MERCK PATENT GMBH (DE) | 2014-10-15 | — | — | EP | claimed |