Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 16/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16162126 | 0.90 | BRAF (0.44) | MAP3K20BRAF | |
| SCHEMBL16162115 | 0.89 | MAP3K20 (0.50) | MAP3K20BRAF | |
| SCHEMBL16162139 | 0.87 | BRAF (0.46) | MAP3K20BRAF | |
| SCHEMBL16162118 | 0.87 | CYP2C9 (0.46) | BRAF | |
| SCHEMBL16162146 | 0.86 | BRAF (0.45) | MAP3K20BRAF | |
| SCHEMBL16162087 | 0.86 | MAP3K20 (0.47) | MAP3K20BRAFCDK8 | |
| SCHEMBL16162151 | 0.86 | CYP2D6 (0.43) | BRAFCYP2D6 | |
| SCHEMBL16162082 | 0.85 | BRAF (0.62) | MAP3K20BRAF | |
| SCHEMBL16162153 | 0.84 | BRAF (0.44) | MAP3K20BRAFCYP2D6CDK8 | |
| SCHEMBL298785 | 0.84 | BRAF (0.48) | MAP3K20BRAFCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170830-B1 | 2-FLUORO-BENZENESULFONAMIDE COMPOUNDS AS Raf KINASE MODULATORS | PLEXXIKON INC (US) | 2014-10-15 | — | — | EP | claimed |