Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.41 |
| ▸ | WNT1 | P04628 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 2/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 8/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | PFKFB3 | Q16875 | 3/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | YES1 | P07947 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL781221 | 1.00 | GSK3B (0.41) | GSK3BDYRK1AWNT1ROCK2MET | |
| SCHEMBL781950 | 0.86 | SCD (0.40) | GSK3BDYRK1AROCK2TBK1PFKFB3 | |
| SCHEMBL780128 | 0.85 | PFKFB3 (0.38) | ROCK2TBK1PFKFB3MAPK1 | |
| SCHEMBL781210 | 0.85 | FGFR4 (0.44) | GSK3BROCK2PFKFB3 | |
| SCHEMBL780503 | 0.79 | PFKFB3 (0.43) | GSK3BDYRK1AWNT1ROCK2TBK1 | |
| SCHEMBL782116 | 0.79 | AOC3 (0.41) | GSK3BDYRK1AWNT1ROCK2MET | |
| Hydrochloric Acid SCHEMBL16161587 | 0.78 | PFKFB3 (0.42) | GSK3BDYRK1AWNT1ROCK2TBK1 | |
| SCHEMBL27868791 | 0.76 | KCNH2 (0.43) | JAK3PFKFB3 | |
| SCHEMBL780785 | 0.76 | KCNH2 (0.43) | JAK3PFKFB3 | |
| SCHEMBL781898 | 0.72 | MAPK1 (0.47) | GSK3BDYRK1AWNT1ROCK2MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435423-B1 | SUBSTITUTED BENZOTRIAZINES AND QUINOXALINES AS INHIBITORS OF P70S6 KINASE | SENTINEL ONCOLOGY LTD (GB) | 2014-10-15 | — | — | EP | disclosed |