⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1616295 | 1.00 | — | — | |
| SCHEMBL9454497 | 0.76 | — | — | |
| SCHEMBL10192448 | 0.75 | — | — | |
| SCHEMBL9454495 | 0.75 | — | — | |
| SCHEMBL9454491 | 0.75 | — | — | |
| SCHEMBL7755759 | 0.75 | — | — | |
| SCHEMBL467876 | 0.74 | — | — | |
| SCHEMBL9584211 | 0.73 | MAPT (0.56) | — | |
| SCHEMBL9584227 | 0.73 | MAPT (0.56) | — | |
| SCHEMBL5321711 | 0.73 | HCAR2 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2670406-B1 | COMBINATION THERAPY WITH INTERFERON BETA AND ANDROGRAPHOLIDES FOR MULTIPLE SCLEROSIS | INNOBIOSCIENCE LLC (US) | 2015-09-02 | — | — | EP | claimed |
| US-9060994-B2 | Combination therapy with interferon and andrographolides for Multiple Sclerosis | Inno Biosciences, S.p.A. (CL) | 2015-06-23 | — | — | US | claimed |
| US-20140301981-A1 | Combination Therapy with Interferon and Andrographolides for Multiple Sclerosis | INNOBIOSCIENCE LLC (US) | 2014-10-09 | — | — | US | claimed |
| EP-2670406-A1 | COMBINATION THERAPY WITH INTERFERON AND ANDROGRAPHOLIDES FOR MULTIPLE SCLEROSIS | Herbal Powers Corporation (US) | 2013-12-11 | — | — | EP | claimed |
| WO-2013096423-A1 | COMBINATION THERAPY WITH INTERFERON AND ANDROGRAPHOLIDES FOR MULTIPLE SCLEROSIS | Herbal Powers Corporation (US) | 2013-06-27 | — | — | WO | claimed |
| US-20220409573-A1 | Hippocampus Regeneration And Memory Recovery | INNOBIOSCIENCE, LLC (US) | 2022-12-29 | — | — | US | disclosed |
| US-10722492-B2 | Andrographolide treats progressive forms of multiple sclerosis | Inno Bioscience, LLC (US) | 2020-07-28 | — | — | US | disclosed |
| US-20190083458-A1 | Andrographolide Treats Progressive Forms of Multiple Sclerosis | INNOBIOSCIENCES, LLC (US) | 2019-03-21 | — | — | US | disclosed |
| US-9060994-B2 | Combination therapy with interferon and andrographolides for Multiple Sclerosis | Inno Biosciences, S.p.A. (CL) | 2015-06-23 | — | — | US | disclosed |
| US-20140301981-A1 | Combination Therapy with Interferon and Andrographolides for Multiple Sclerosis | INNOBIOSCIENCE LLC (US) | 2014-10-09 | — | — | US | disclosed |
| EP-1794122-B1 | 3-SUBSTITUTED-5- AND 6-AMINOALKYL INDOLE-2-CARBOXYLIC ACID AMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I | AVENTIS PHARMA INC (US) | 2011-05-04 | — | — | EP | disclosed |
| US-7923466-B2 | treating in a lengthening of circadian rhythm period with 6-aminomethyl-3-phenylsulfanyl-1H-indole-2-carboxylic acid amide; for treating central nervous system diseases and mood disorders, bipolar disorder and sleep disorders, with an enzyme inhibitor | AVENTIS PHARMACEUTICALS INC. (US) | 2011-04-12 | — | — | US | disclosed |
| US-7629376-B2 | 3-substituted-5- and 6-aminoalkyl indole-2-carboxylic acid amides and related analogs as inhibitors of casein kinase I | AVENTIS PHARMACEUTICALS INC. (US) | 2009-12-08 | — | — | US | disclosed |
| US-20090082340-A1 | 3-SUBSTITUTED-5- AND 6-AMINOALKYL INDOLE-2-CARBOXYLIC ACID AMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I | AVENTIS PHARMACEUTICALS INC. (US) | 2009-03-26 | — | — | US | disclosed |
| US-20080027124-A1 | 3-SUBSTITUTED-5- AND 6-AMINOALKYL INDOLE-2-CARBOXYLIC ACID AMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I | AVENTIS PHARMACEUTICALS INC. (US) | 2008-01-31 | — | — | US | disclosed |
| US-20040023882-A1 | PTH derivatives resistant to skin proteases | THERATECHNOLOGIES INC. (CA) | 2004-02-05 | — | — | US | disclosed |
| WO-2003097690-A2 | PTH DERIVATIVES RESISTANT TO SKIN PROTEASES | THERATECHNOLOGIES INC. (CA) | 2003-11-27 | — | — | WO | disclosed |