Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16166022 | 0.93 | BACE1 (0.32) | BACE1 | |
| SCHEMBL17511226 | 0.93 | BACE1 (0.32) | BACE1 | |
| SCHEMBL16166021 | 0.93 | BACE1 (0.32) | BACE1 | |
| SCHEMBL17511227 | 0.93 | BACE1 (0.32) | BACE1 | |
| SCHEMBL16166378 | 0.87 | — | — | |
| SCHEMBL16166148 | 0.86 | BACE1 (0.32) | BACE1 | |
| SCHEMBL16166146 | 0.86 | BACE1 (0.32) | BACE1 | |
| SCHEMBL16166150 | 0.86 | BACE1 (0.32) | BACE1 | |
| SCHEMBL30088443 | 0.86 | BACE1 (0.32) | BACE1 | |
| SCHEMBL16166100 | 0.82 | BACE1 (0.34) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2984086-A1 | BACE1 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2016-02-17 | — | — | EP | disclosed |
| WO-2014166906-A1 | BACE1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-10-16 | — | — | WO | disclosed |