Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 15/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.51 |
| ▸ | PDE4A | P27815 | 11/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1616663 | 0.89 | PDE4D (0.50) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL1616665 | 0.89 | PDE4D (0.50) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL27910418 | 0.87 | PDE4D (0.40) | PDE4DPDE4BPDE4APDE4CSMN1; SMN2 | |
| SCHEMBL15760708 | 0.87 | PDE4D (0.62) | PDE4DPDE4BPDE4APDE4CCHRM3 | |
| SCHEMBL19559279 | 0.86 | PDE4B (0.47) | PDE4DPDE4BPDE4APDE4CSMN1; SMN2 | |
| SCHEMBL14240228 | 0.85 | TDP1 (0.52) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL14352917 | 0.85 | TDP1 (0.52) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL14240232 | 0.85 | TDP1 (0.52) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL1616664 | 0.85 | TDP1 (0.52) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL14165076 | 0.85 | TDP1 (0.52) | PDE4DPDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2022783-A1 | \"Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors\ | CHIESI FARMACEUTICI S.p.A. (IT) | 2009-02-11 | — | — | EP | claimed |
| EP-2947068-B1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARM SPA (IT) | 2017-11-08 | — | — | EP | disclosed |
| EP-2947068-B1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARM SPA (IT) | 2017-11-08 | — | — | EP | disclosed |
| EP-2185515-B1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMA SPA (IT) | 2016-01-06 | — | — | EP | disclosed |
| EP-2185515-B1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMA SPA (IT) | 2016-01-06 | — | — | EP | disclosed |
| EP-2947068-A1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.p.A. (IT) | 2015-11-25 | — | — | EP | disclosed |
| EP-2947068-A1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.p.A. (IT) | 2015-11-25 | — | — | EP | disclosed |
| US-9102619-B2 | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-08-11 | — | — | US | disclosed |
| US-9102619-B2 | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-08-11 | — | — | US | disclosed |
| US-9102619-B2 | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-08-11 | — | — | US | disclosed |
| US-20110144075-A1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-06-16 | — | — | US | disclosed |
| US-20110144075-A1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-06-16 | — | — | US | disclosed |
| US-20110144075-A1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-06-16 | — | — | US | disclosed |
| US-7923565-B2 | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-04-12 | — | — | US | disclosed |
| EP-2185515-A2 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.p.A. (IT) | 2010-05-19 | — | — | EP | disclosed |
| US-20090048220-A1 | for respiratory tract diseases characterized by airway obstruction such as asthma and COPD; 3-cyclopropylmethoxy-4-difluoromethoxy-benzoic acid 1-(3-cyclopropylmethoxy-4-difluoromethoxy-phenyl)-2-(3,5-dichloro-1-oxy-pyridin-4-yl)-ethyl ester | CHIESI FARMACEUTICI S.P.A. (IT) | 2009-02-19 | — | — | US | disclosed |
| WO-2009018909-A2 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2009-02-12 | — | — | WO | disclosed |
| WO-2009018909-A2 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2009-02-12 | — | — | WO | disclosed |
| EP-2022783-A1 | \"Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors\ | CHIESI FARMACEUTICI S.p.A. (IT) | 2009-02-11 | — | — | EP | disclosed |
| EP-2022783-A1 | \"Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors\ | CHIESI FARMACEUTICI S.p.A. (IT) | 2009-02-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144075-A1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | PDE4A, PDE4B, PDE3A | PDE4D 8/4885PDE4B 2/4885PDE4A 1/4885 |
| US-20090048220-A1 | for respiratory tract diseases characterized by airway obstruction such as asthma and COPD; 3-cyclopropylmethoxy-4-difluoromethoxy-benzoic acid 1-(3-cyclopropylmethoxy-4-difluoromethoxy-phenyl)-2-(3,5-dichloro-1-oxy-pyridin-4-yl)-ethyl ester | PDE4A, PDE4B, PDE12 | PDE4D 4/4885PDE4B 2/4885PDE4A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.