Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16175856 | 0.85 | SMN1; SMN2 (0.60) | MAPTSMN1; SMN2HTTKMT2AMEN1 | |
| SCHEMBL689308 | 0.78 | SMN1; SMN2 (0.64) | MAPTSMN1; SMN2HTTKMT2APOLB | |
| SCHEMBL27967955 | 0.78 | MAPT (0.53) | MAPTSMN1; SMN2HTTKMT2APOLB | |
| SCHEMBL1951448 | 0.77 | MAPT (0.49) | MAPTSMN1; SMN2HTTKMT2APOLB | |
| SCHEMBL16175862 | 0.75 | MAPT (0.54) | MAPTSMN1; SMN2HTTKMT2APOLB | |
| SCHEMBL16166660 | 0.75 | MAPT (0.54) | MAPTSMN1; SMN2HTTKMT2APOLB | |
| SCHEMBL16166659 | 0.75 | MAPT (0.54) | MAPTSMN1; SMN2HTTKMT2APOLB | |
| SCHEMBL13139938 | 0.75 | SMN1; SMN2 (0.85) | MAPTSMN1; SMN2HTTKMT2APOLB | |
| SCHEMBL3072808 | 0.75 | SMN1; SMN2 (0.80) | MAPTSMN1; SMN2HTTKMT2APOLB | |
| SCHEMBL3457084 | 0.75 | POLB (0.61) | SMN1; SMN2HTTKMT2APOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014167444-A1 | SUBSTITUTED BICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2014-10-16 | — | — | WO | disclosed |
| WO-2014167444-A1 | SUBSTITUTED BICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2014-10-16 | — | — | WO | disclosed |