Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.47 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 4/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | LPL | P06858 | 1/20 | 0.30 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15555039 | 0.90 | AAK1 (0.49) | AAK1DGAT1ALPLPDGFRBKDR | |
| SCHEMBL10324441 | 0.89 | AAK1 (0.51) | AAK1DGAT1ALPLPDGFRBKDR | |
| SCHEMBL365904 | 0.85 | AAK1 (0.51) | AAK1DGAT1ALPLPDGFRBKDR | |
| SCHEMBL16175289 | 0.82 | AAK1 (0.43) | AAK1DGAT1ALPLPDGFRBKDR | |
| SCHEMBL22484225 | 0.81 | AAK1 (0.42) | AAK1DGAT1ALPLPDGFRBKDR | |
| SCHEMBL27314904 | 0.81 | AAK1 (0.45) | AAK1DGAT1ALPLPDGFRBKDR | |
| SCHEMBL30864874 | 0.81 | AAK1 (0.45) | AAK1DGAT1ALPLPDGFRBKDR | |
| SCHEMBL16175400 | 0.80 | AAK1 (0.47) | AAK1DGAT1ALPLPDGFRBKDR | |
| SCHEMBL367669 | 0.79 | AAK1 (0.43) | AAK1DGAT1ALPLPDGFRBKDR | |
| SCHEMBL26464168 | 0.79 | AAK1 (0.51) | AAK1DGAT1ALPLPDGFRBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593431-B1 | N-SULFONYLBENZAMIDES AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | PFIZER LTD (GB) | 2014-11-19 | — | — | EP | disclosed |
| EP-2593432-B1 | N-SULFONYLBENZAMIDE DERIVATIVES USEFUL AS VOLTAGE GATED SODIUM CHANNEL INHIBITORS | PFIZER LTD (GB) | 2014-10-22 | — | — | EP | disclosed |