SCHEMBL16175142

SCHEMBL16175142

Cc1ccc(OC(=O)c2cc(Cl)c(Oc3cnc(OCC(C)C)c(Cl)c3)cc2F)cc1

nearest known ligand 0.64

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 20/20 0.64
SCN5A Q14524 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16175107 0.93 SCN9A (0.55) SCN9ASCN5A
SCHEMBL16175104 0.89 SCN9A (0.49) SCN9ASCN5A
SCHEMBL10198369 0.88 SCN9A (0.49) SCN9ASCN5A
SCHEMBL16175064 0.87 SCN9A (0.57) SCN9ASCN5A
SCHEMBL16175597 0.87 SCN9A (0.47) SCN9ASCN5A
SCHEMBL16175129 0.86 SCN9A (0.52) SCN9ASCN5A
SCHEMBL16175450 0.86 SCN9A (0.47) SCN9ASCN5A
SCHEMBL363691 0.85 SCN9A (0.47) SCN9ASCN5A
SCHEMBL16175398 0.85 SCN9A (0.51) SCN9ASCN5A
SCHEMBL365036 0.85 SCN9A (0.47) SCN9ASCN5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2593432-B1 N-SULFONYLBENZAMIDE DERIVATIVES USEFUL AS VOLTAGE GATED SODIUM CHANNEL INHIBITORS PFIZER LTD (GB) 2014-10-22 EP disclosed