Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 13/20 | 0.49 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.47 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.45 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.45 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | IGFBP3 | P17936 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16175156 | 0.89 | SCN9A (0.51) | SCN9AKCNQ3KCNQ2SCN5AKCNE1 | |
| SCHEMBL15543736 | 0.87 | SCN9A (0.49) | SCN9ASCN5APTGER4ACACB | |
| SCHEMBL365976 | 0.85 | SCN9A (0.46) | SCN9AKCNQ3KCNQ2SCN5APTGER4 | |
| SCHEMBL16175333 | 0.85 | SCN9A (0.58) | SCN9ASCN5A | |
| SCHEMBL365758 | 0.83 | SCN9A (0.55) | SCN9ASCN5A | |
| SCHEMBL15543257 | 0.83 | SCN9A (0.68) | SCN9ASCN5APTGER4ACACB | |
| SCHEMBL19411389 | 0.81 | SCN9A (0.56) | SCN9ASCN5A | |
| SCHEMBL17176913 | 0.80 | SCN9A (0.55) | SCN9ASCN5A | |
| SCHEMBL16175147 | 0.80 | SCN9A (0.50) | SCN9ASCN5A | |
| SCHEMBL16175271 | 0.80 | SCN9A (0.50) | SCN9ASCN5AACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593432-B1 | N-SULFONYLBENZAMIDE DERIVATIVES USEFUL AS VOLTAGE GATED SODIUM CHANNEL INHIBITORS | PFIZER LTD (GB) | 2014-10-22 | — | — | EP | disclosed |