Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 20/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16177573 | 1.00 | EZH2 (0.56) | EZH2 | |
| SCHEMBL16189785 | 0.87 | EZH2 (0.51) | EZH2 | |
| SCHEMBL16177233 | 0.83 | EZH2 (0.61) | EZH2 | |
| SCHEMBL16177236 | 0.83 | EZH2 (0.61) | EZH2 | |
| SCHEMBL16177397 | 0.82 | EZH2 (0.59) | EZH2 | |
| SCHEMBL16177392 | 0.82 | EZH2 (0.59) | EZH2 | |
| SCHEMBL16177249 | 0.82 | EZH2 (0.62) | EZH2 | |
| SCHEMBL16177350 | 0.81 | EZH2 (0.53) | EZH2 | |
| SCHEMBL16177351 | 0.81 | EZH2 (0.53) | EZH2 | |
| SCHEMBL16186249 | 0.81 | EZH2 (0.61) | EZH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160244464-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. | 2016-08-25 | — | — | US | disclosed |
| US-20160031907-A1 | Substituted Benzene Compounds | Epizyme, Inc. | 2016-02-04 | — | — | US | disclosed |
| US-9243001-B2 | Substituted benzene compounds | Epizyme, Inc. (US) | 2016-01-26 | — | — | US | disclosed |
| EP-2970281-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014172044-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2014-10-23 | — | — | WO | disclosed |
| US-20140315945-A1 | Substituted Benzene Compounds | Epizyme, Inc. (US) | 2014-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160031907-A1 | Substituted Benzene Compounds | CYP1B1, CYP4B1, CYP2B6 | EZH2 2658/4885 |
| US-20140315945-A1 | Substituted Benzene Compounds | VHL, AHR, TP53 | EZH2 1601/4885 |
| US-20160244464-A1 | SUBSTITUTED BENZENE COMPOUNDS | VHL, AHR, TP53 | EZH2 1601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.