Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14357960 | 0.82 | KDM4E (0.44) | KDM4EPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30025575 | 0.82 | KDM4E (0.44) | KDM4EPDE4APDE4BPDE4CPDE4D | |
| Acetic Acid SCHEMBL28009762 | 0.74 | PDE4A (0.48) | KDM4EPDE4APDE4BPDE4CPDE4D | |
| Methyl Alcohol SCHEMBL8114753 | 0.72 | — | — | |
| SCHEMBL60851 | 0.72 | — | — | |
| SCHEMBL7145695 | 0.72 | — | — | |
| SCHEMBL2645473 | 0.71 | DAO (0.39) | KDM4EPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30945175 | 0.71 | DAO (0.39) | KDM4EPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28452581 | 0.71 | GRM4 (0.44) | PDE4APDE4BPDE4CPDE4DGRM4 | |
| SCHEMBL10919241 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014170792-A1 | SULFONAMIDE DERIVATIVES AS URAT-1 INHIBITORS | PFIZER LIMITED (GB) | 2014-10-23 | — | — | WO | disclosed |