Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.56 |
| ▸ | MTOR | P42345 | 2/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.56 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.41 |
| ▸ | PAK4 | O96013 | 8/20 | 0.40 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.40 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | CD38 | P28907 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16179566 | 0.76 | PAK4 (0.64) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL11970464 | 0.76 | PAK4 (0.41) | PIK3CAMTORIRAK4PAK4PAK1 | |
| SCHEMBL16179410 | 0.74 | PAK4 (0.77) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL16179407 | 0.74 | PAK4 (0.77) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL11971011 | 0.73 | PAK4 (0.60) | PIK3CAMTORPIK3CDPIK3CBPAK4 | |
| SCHEMBL9948516 | 0.72 | MTOR (1.00) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL11970572 | 0.68 | PAK4 (0.41) | PIK3CAMTORPAK4PAK1PKN1 | |
| SCHEMBL31006575 | 0.67 | IRAK4 (0.74) | IRAK4CD38 | |
| SCHEMBL29283852 | 0.67 | IRAK4 (0.74) | IRAK4CD38 | |
| SCHEMBL3791184 | 0.66 | MTOR (0.88) | PIK3CAMTORPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014170421-A1 | SERINE/THREONINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-10-23 | — | — | WO | disclosed |