Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | EZH2 | Q15910 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 2/20 | 0.33 |
| ▸ | CHUK | O15111 | 2/20 | 0.33 |
| ▸ | IKBKG | Q9Y6K9 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3477117 | 0.91 | SLC2A1 (0.42) | SLC2A1MAPK8MAPK9EZH2KCNH2 | |
| SCHEMBL3471336 | 0.88 | KDR (0.40) | KDRKCNH2AKT3IKBKBCHUK | |
| SCHEMBL3472509 | 0.85 | AKT3 (0.41) | SLC2A1MAPK8MAPK9KDRKCNH2 | |
| SCHEMBL13638560 | 0.81 | MAPK8 (0.39) | SLC2A1MAPK8MAPK9KDREZH2 | |
| SCHEMBL3471003 | 0.81 | KCNH2 (0.37) | MAPK8MAPK9KDRKCNH2IKBKB | |
| SCHEMBL3478419 | 0.80 | IKBKB (0.47) | KDRKCNH2AKT3IKBKBCHUK | |
| SCHEMBL4492547 | 0.80 | IKBKB (0.43) | KDRKCNH2AKT3IKBKBCHUK | |
| SCHEMBL3477954 | 0.80 | IKBKB (0.38) | KDRKCNH2AKT3IKBKBCHUK | |
| SCHEMBL3470336 | 0.80 | KCNH2 (0.37) | MAPK8MAPK9KDRKCNH2AKT3 | |
| SCHEMBL13633566 | 0.79 | IKBKB (0.45) | KDRKCNH2AKT3IKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615898-B1 | 2-Aminopyrimidine derivatives and their medical use | NOVARTIS AG (CH) | 2014-10-29 | — | — | EP | claimed |