Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.65 |
| ▸ | JAK2 | O60674 | 1/20 | 0.65 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.65 |
| ▸ | FYN | P06241 | 1/20 | 0.65 |
| ▸ | FGR | P09769 | 1/20 | 0.65 |
| ▸ | SRC | P12931 | 1/20 | 0.65 |
| ▸ | FER | P16591 | 1/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.65 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.65 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.65 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.65 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.65 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16197811 | 1.00 | SYK (0.65) | SYKJAK2NTRK1FYNFGR | |
| SCHEMBL17536788 | 1.00 | SYK (0.65) | SYKJAK2NTRK1FYNFGR | |
| SCHEMBL12193922 | 0.92 | SYK (0.58) | SYKJAK2NTRK1FYNFGR | |
| SCHEMBL17536864 | 0.90 | SYK (0.72) | SYKJAK2NTRK1FYNFGR | |
| SCHEMBL15304322 | 0.90 | SYK (0.72) | SYKJAK2NTRK1FYNFGR | |
| SCHEMBL2506225 | 0.90 | SYK (0.72) | SYKJAK2NTRK1FYNFGR | |
| SCHEMBL2498272 | 0.90 | SYK (0.72) | SYKJAK2NTRK1FYNFGR | |
| SCHEMBL2036975 | 0.85 | SYK (0.56) | SYKJAK2NTRK1FYNFGR | |
| SCHEMBL13518388 | 0.84 | SYK (0.53) | SYKJAK2NTRK1FYNFGR | |
| SCHEMBL2046206 | 0.82 | SYK (0.85) | SYKJAK2NTRK1FYNFGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2988744-A1 | THIAZOLE-SUBSTITUTED AMINOHETEROARYLS AS SPLEEN TYROSINE KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2016-03-02 | — | — | EP | disclosed |
| WO-2014176210-A1 | THIAZOLE-SUBSTITUTED AMINOHETEROARYLS AS SPLEEN TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-10-30 | — | — | WO | disclosed |