Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.66 |
| ▸ | PDE6C | P51160 | 3/20 | 0.53 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.53 |
| ▸ | PDE1A | P54750 | 1/20 | 0.53 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.53 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.53 |
| ▸ | PDE6D | O43924 | 1/20 | 0.45 |
| ▸ | PDE6A | P16499 | 1/20 | 0.45 |
| ▸ | PDE6G | P18545 | 1/20 | 0.45 |
| ▸ | PDE6B | P35913 | 1/20 | 0.45 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2564928 | 0.93 | PDE5A (0.71) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL16198855 | 0.91 | PDE5A (0.68) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL2562874 | 0.91 | PDE5A (0.68) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL16198829 | 0.83 | PDE5A (0.72) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL2567179 | 0.82 | PDE5A (0.74) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL16198865 | 0.81 | PDE5A (0.72) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL16198827 | 0.80 | PDE5A (0.63) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL16198837 | 0.80 | PDE5A (1.00) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL2560389 | 0.79 | PDE5A (0.72) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL16198816 | 0.78 | PDE5A (0.71) | PDE5APDE6CPDE11APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2383262-B1 | PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF | TOPHARMAN SHANGHAI CO LTD (CN) | 2016-07-06 | — | — | EP | disclosed |
| US-8871777-B2 | Phenylpyrimidone compounds, the pharmaceutical compositions, preparation methods and uses thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2014-10-28 | — | — | US | disclosed |
| US-8871777-B2 | Phenylpyrimidone compounds, the pharmaceutical compositions, preparation methods and uses thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2014-10-28 | — | — | US | disclosed |