Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 19/20 | 0.70 |
| ▸ | PDE6D | O43924 | 3/20 | 0.61 |
| ▸ | PDE6A | P16499 | 3/20 | 0.61 |
| ▸ | PDE6G | P18545 | 3/20 | 0.61 |
| ▸ | PDE6B | P35913 | 3/20 | 0.61 |
| ▸ | PDE6C | P51160 | 3/20 | 0.61 |
| ▸ | PDE6H | Q13956 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16198833 | 0.92 | PDE5A (0.79) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL16198830 | 0.92 | PDE5A (0.79) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL2563344 | 0.84 | PDE5A (0.74) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL2567803 | 0.82 | PDE5A (1.00) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL16188246 | 0.82 | PDE5A (0.67) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL2568505 | 0.82 | PDE5A (1.00) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL16198829 | 0.81 | PDE5A (0.72) | PDE5APDE6CHPGDHSD17B10 | |
| SCHEMBL16198818 | 0.81 | PDE5A (0.64) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL16198820 | 0.80 | PDE5A (0.65) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL2562266 | 0.79 | PDE5A (0.69) | PDE5APDE6DPDE6APDE6GPDE6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871777-B2 | Phenylpyrimidone compounds, the pharmaceutical compositions, preparation methods and uses thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2014-10-28 | — | — | US | disclosed |
| US-8871777-B2 | Phenylpyrimidone compounds, the pharmaceutical compositions, preparation methods and uses thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2014-10-28 | — | — | US | disclosed |