Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 19/20 | 0.59 |
| ▸ | PDE6C | P51160 | 2/20 | 0.55 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.55 |
| ▸ | PDE1A | P54750 | 1/20 | 0.55 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.55 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.55 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.51 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.51 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16198839 | 0.85 | PDE5A (0.56) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL16199262 | 0.84 | PDE5A (0.73) | PDE5APDE6CPDE11A | |
| SCHEMBL16188189 | 0.83 | PDE5A (0.62) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL16198870 | 0.83 | PDE5A (0.67) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL2566787 | 0.82 | PDE5A (0.60) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL2565794 | 0.82 | PDE5A (0.63) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL2569995 | 0.81 | PDE5A (0.66) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL2565050 | 0.81 | PDE5A (0.61) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL2563968 | 0.81 | PDE5A (0.60) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL2564557 | 0.81 | PDE5A (0.56) | PDE5APDE6CPDE11APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2383262-B1 | PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF | TOPHARMAN SHANGHAI CO LTD (CN) | 2016-07-06 | — | — | EP | disclosed |
| US-8871777-B2 | Phenylpyrimidone compounds, the pharmaceutical compositions, preparation methods and uses thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2014-10-28 | — | — | US | disclosed |
| US-8871777-B2 | Phenylpyrimidone compounds, the pharmaceutical compositions, preparation methods and uses thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2014-10-28 | — | — | US | disclosed |