Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.65 |
| ▸ | PDE6C | P51160 | 2/20 | 0.55 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.55 |
| ▸ | PDE1A | P54750 | 1/20 | 0.55 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.55 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16188188 | 0.88 | PDE5A (0.69) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL16198854 | 0.86 | PDE5A (0.62) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL16198850 | 0.85 | PDE5A (0.62) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL16198845 | 0.85 | PDE5A (0.62) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL16198843 | 0.84 | PDE5A (0.60) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL16198841 | 0.84 | PDE5A (0.60) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL16198849 | 0.84 | PDE5A (0.61) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL17888957 | 0.83 | PDE5A (0.64) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL16188217 | 0.83 | PDE5A (0.64) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL16198847 | 0.83 | PDE5A (0.59) | PDE5APDE6CPDE11APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871777-B2 | Phenylpyrimidone compounds, the pharmaceutical compositions, preparation methods and uses thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2014-10-28 | — | — | US | disclosed |