Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.70 |
| ▸ | PDE6C | P51160 | 3/20 | 0.57 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.57 |
| ▸ | PDE1A | P54750 | 1/20 | 0.57 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.57 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.57 |
| ▸ | PDE6D | O43924 | 1/20 | 0.54 |
| ▸ | PDE6A | P16499 | 1/20 | 0.54 |
| ▸ | PDE6G | P18545 | 1/20 | 0.54 |
| ▸ | PDE6B | P35913 | 1/20 | 0.54 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16198809 | 0.90 | PDE5A (0.69) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL16198814 | 0.90 | PDE5A (0.69) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL16198874 | 0.89 | PDE5A (0.70) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL16198807 | 0.89 | PDE5A (0.70) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL16198868 | 0.89 | PDE5A (0.70) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL16198796 | 0.88 | PDE5A (0.73) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL16198794 | 0.85 | PDE5A (0.60) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL16198806 | 0.84 | PDE5A (0.71) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL16198811 | 0.84 | PDE5A (0.54) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL16198804 | 0.83 | PDE5A (0.71) | PDE5APDE6CPDE6DPDE6APDE6G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871777-B2 | Phenylpyrimidone compounds, the pharmaceutical compositions, preparation methods and uses thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2014-10-28 | — | — | US | disclosed |