Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 2/20 | 0.47 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.47 |
| ▸ | AXL | P30530 | 9/20 | 0.46 |
| ▸ | NEK1 | Q96PY6 | 4/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL878758 | 0.86 | AAK1 (0.56) | AAK1BRD4PAK1AXLNEK1 | |
| SCHEMBL857422 | 0.73 | AXL (0.61) | AAK1PAK1AXLNEK1IGF1R | |
| SCHEMBL857618 | 0.72 | AAK1 (0.52) | AAK1BRD4PAK1AXLNEK1 | |
| SCHEMBL857604 | 0.72 | NEK1 (0.57) | AAK1BRD4AXLNEK1NTRK1 | |
| SCHEMBL413738 | 0.72 | PAK1 (0.60) | AAK1PAK1AXLIGF1REGFR | |
| SCHEMBL858329 | 0.72 | AAK1 (0.67) | AAK1AXLNEK1CDC7PLK4 | |
| SCHEMBL857550 | 0.72 | AAK1 (0.58) | AAK1AXLNEK1DYRK3ROCK2 | |
| SCHEMBL3699186 | 0.71 | NTRK1 (0.64) | AAK1BRD4AXLNEK1CDC7 | |
| SCHEMBL3699180 | 0.71 | DYRK1A (0.58) | AAK1BRD4AXLNEK1CDC7 | |
| SCHEMBL856972 | 0.71 | NEK1 (0.61) | AAK1BRD4AXLNEK1DYRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696920-B1 | COMPOUNDS AND METHODS FOR DEVELOPMENT OF RET MODULATORS | PLEXXIKON INC (US) | 2014-10-29 | — | — | EP | disclosed |