Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 3/20 | 0.43 |
| ▸ | PAK1 | Q13153 | 6/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.42 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.40 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.40 |
| ▸ | BRAF | P15056 | 4/20 | 0.39 |
| ▸ | SGK1 | O00141 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL857852 | 0.86 | MAP3K11 (0.49) | AXLPAK1AAK1CAMKK2SGK1 | |
| SCHEMBL857911 | 0.82 | KIT (0.52) | AXLPAK1AAK1PKN1PIK3CA | |
| SCHEMBL858062 | 0.81 | AXL (0.56) | AXLPAK1AAK1CAMKK2 | |
| SCHEMBL858780 | 0.80 | BRD4 (0.51) | AXLPAK1AAK1PIK3CA | |
| SCHEMBL27804369 | 0.80 | AAK1 (0.42) | AXLPAK1AAK1PKN1CAMKK2 | |
| SCHEMBL10263401 | 0.80 | AAK1 (0.49) | AXLPAK1AAK1SGK1PIK3CA | |
| SCHEMBL857729 | 0.77 | BRAF (0.42) | AXLPAK1AAK1PKN1BRAF | |
| SCHEMBL4301666 | 0.76 | PIK3CA (0.51) | AXLPAK1CAMKK2BRAFPIK3CA | |
| SCHEMBL859107 | 0.75 | AXL (0.45) | AXLPAK1AAK1PKN1CAMKK2 | |
| SCHEMBL1364902 | 0.75 | AXL (0.45) | AXLPAK1AAK1PKN1CAMKK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696920-B1 | COMPOUNDS AND METHODS FOR DEVELOPMENT OF RET MODULATORS | PLEXXIKON INC (US) | 2014-10-29 | — | — | EP | disclosed |