Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 17/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL856983 | 0.85 | CYP3A4 (0.47) | BTKEGFRALDH1A1PKML3MBTL1 | |
| SCHEMBL858383 | 0.78 | LRRK2 (0.49) | BTKEGFRALDH1A1PKML3MBTL1 | |
| SCHEMBL857037 | 0.77 | CYP1A2 (0.51) | BTKEGFRALDH1A1PKMMAPK7 | |
| SCHEMBL857191 | 0.77 | LRRK2 (0.49) | BTKEGFRALDH1A1PKML3MBTL1 | |
| SCHEMBL856845 | 0.75 | PIM1 (0.60) | BTKALDH1A1PKML3MBTL1 | |
| SCHEMBL857272 | 0.75 | LRRK2 (0.43) | BTKEGFRALDH1A1PKML3MBTL1 | |
| SCHEMBL856895 | 0.74 | PRKCI (0.51) | BTKEGFRALDH1A1PKML3MBTL1 | |
| SCHEMBL856988 | 0.73 | PRKAA1 (0.48) | BTK | |
| SCHEMBL1364351 | 0.73 | PIM2 (0.45) | BTKEGFRALDH1A1PKML3MBTL1 | |
| SCHEMBL857900 | 0.73 | PIM2 (0.45) | BTKEGFRALDH1A1PKML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696920-B1 | COMPOUNDS AND METHODS FOR DEVELOPMENT OF RET MODULATORS | PLEXXIKON INC (US) | 2014-10-29 | — | — | EP | disclosed |