Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.60 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.45 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.45 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.45 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.45 |
| ▸ | GRM6 | O15303 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28798270 | 0.95 | MAPT (0.57) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL11697944 | 0.85 | MAPT (0.57) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL19314788 | 0.82 | MAPT (0.42) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL31633231 | 0.79 | MAPT (0.45) | MAPTHPGDBLMALDH1A1MEN1 | |
| SCHEMBL1625765 | 0.77 | MAPT (0.74) | MAPTPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL25387459 | 0.77 | MAPT (0.44) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL25386141 | 0.76 | CYP1A2 (0.41) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL16253983 | 0.76 | MAPT (0.66) | MAPTCYP1A2POLBCYP2C9BLM | |
| SCHEMBL25387549 | 0.76 | MAPT (0.53) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL30514043 | 0.76 | MAPT (0.53) | MAPTGRIA1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2796461-B1 | METHODS OF PREPARING ICOTINIB AND ICOTINIB HYDROCHLORIDE, AND INTERMEDIATES THEREOF | BETTA PHARMACEUTICALS CO LTD (CN) | 2017-09-06 | — | — | EP | disclosed |
| US-9085588-B2 | Methods of preparing icotinib and icotinib hydrochloride, and intermediates thereof | BETTA PHARMACEUTICALS CO., LTD. (CN) | 2015-07-21 | — | — | US | disclosed |
| US-9085588-B2 | Methods of preparing icotinib and icotinib hydrochloride, and intermediates thereof | BETTA PHARMACEUTICALS CO., LTD. (CN) | 2015-07-21 | — | — | US | disclosed |
| US-20140343283-A1 | METHODS OF PREPARING ICOTINIB AND ICOTINIB HYDROCHLORIDE, AND INTERMEDIATES THEREOF | BETTA PHARMACEUTICALS CO., LTD. (CN) | 2014-11-20 | — | — | US | disclosed |
| US-20140343283-A1 | METHODS OF PREPARING ICOTINIB AND ICOTINIB HYDROCHLORIDE, AND INTERMEDIATES THEREOF | BETTA PHARMACEUTICALS CO., LTD. (CN) | 2014-11-20 | — | — | US | disclosed |
| EP-2796461-A1 | METHODS OF PREPARING ICOTINIB AND ICOTINIB HYDROCHLORIDE, AND INTERMEDIATES THEREOF | Beta Pharmaceuticals Co., Ltd. (CN) | 2014-10-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140343283-A1 | METHODS OF PREPARING ICOTINIB AND ICOTINIB HYDROCHLORIDE, AND INTERMEDIATES THEREOF | ABL1, JAK2, ALK | MAPT 2646/4885GRIA1 4492/4885GRIA2 4204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.