Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.57 |
| ▸ | BRD4 | O60885 | 1/20 | 0.55 |
| ▸ | NEK1 | Q96PY6 | 2/20 | 0.53 |
| ▸ | AAK1 | Q2M2I8 | 6/20 | 0.52 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | CDK9 | P50750 | 1/20 | 0.52 |
| ▸ | AXL | P30530 | 2/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3699186 | 0.89 | NTRK1 (0.64) | DYRK1ANTRK1PIK3CABRD4NEK1 | |
| SCHEMBL858151 | 0.89 | PAK1 (0.56) | DYRK1ANTRK1PIK3CABRD4NEK1 | |
| SCHEMBL28770490 | 0.88 | NEK1 (0.58) | DYRK1ANTRK1PIK3CABRD4NEK1 | |
| SCHEMBL10293346 | 0.85 | BRD4 (0.56) | DYRK1ANTRK1PIK3CABRD4NEK1 | |
| SCHEMBL20086218 | 0.85 | DYRK1A (0.56) | DYRK1ANTRK1PIK3CABRD4NEK1 | |
| SCHEMBL3699180 | 0.85 | DYRK1A (0.58) | DYRK1ANTRK1PIK3CABRD4NEK1 | |
| SCHEMBL412715 | 0.84 | BRD4 (0.57) | DYRK1ANTRK1PIK3CABRD4NEK1 | |
| SCHEMBL857604 | 0.83 | NEK1 (0.57) | DYRK1ANTRK1PIK3CABRD4NEK1 | |
| SCHEMBL858911 | 0.82 | BRD4 (0.51) | DYRK1ANTRK1PIK3CABRD4NEK1 | |
| SCHEMBL412853 | 0.82 | NEK1 (0.58) | NTRK1BRD4NEK1AAK1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696920-B1 | COMPOUNDS AND METHODS FOR DEVELOPMENT OF RET MODULATORS | PLEXXIKON INC (US) | 2014-10-29 | — | — | EP | disclosed |