Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 0.54 |
| ▸ | CLK1 | P49759 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.49 |
| ▸ | AXL | P30530 | 4/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.46 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.46 |
| ▸ | PAK1 | Q13153 | 3/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL857049 | 0.89 | MAP3K11 (0.51) | BRAFDYRK1AAXLNTRK1AAK1 | |
| SCHEMBL857042 | 0.89 | BRAF (0.56) | BRAFAXLAAK1CAMKK2PAK1 | |
| SCHEMBL857228 | 0.89 | KIT (0.54) | DYRK1AAXLNTRK1AAK1PAK1 | |
| SCHEMBL858642 | 0.84 | AXL (0.64) | BRAFAXLAAK1CAMKK2PAK1 | |
| SCHEMBL858564 | 0.83 | BRD4 (0.52) | CLK1DYRK1ADYRK1BAXLNTRK1 | |
| SCHEMBL857478 | 0.82 | BRAF (0.49) | BRAFDYRK1AAXLAAK1PAK1 | |
| SCHEMBL14620859 | 0.82 | CYP2C19 (0.45) | BRAFAXLAAK1PAK1CYP2C19 | |
| SCHEMBL857971 | 0.79 | BRAF (0.59) | BRAFAXLPAK1CYP2C19RIPK2 | |
| SCHEMBL3506532 | 0.78 | BRAF (0.56) | BRAFCLK1DYRK1ADYRK2DYRK1B | |
| SCHEMBL416155 | 0.78 | AAK1 (0.53) | BRAFCLK1DYRK1ADYRK2DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696920-B1 | COMPOUNDS AND METHODS FOR DEVELOPMENT OF RET MODULATORS | PLEXXIKON INC (US) | 2014-10-29 | — | — | EP | disclosed |