Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 4/20 | 0.39 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | NEK2 | P51955 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | STK4 | Q13043 | 1/20 | 0.36 |
| ▸ | STK3 | Q13188 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1363679 | 0.88 | LRRK2 (0.51) | PRKCINTRK1PIK3CADYRK1ALRRK2 | |
| SCHEMBL1363467 | 0.87 | LRRK2 (0.55) | PRKCINTRK1DYRK1ALRRK2KIT | |
| SCHEMBL857026 | 0.84 | LRRK2 (0.46) | PRKCINTRK1PIK3CADYRK1ALRRK2 | |
| SCHEMBL856956 | 0.81 | BTK (0.48) | LRRK2BTK | |
| SCHEMBL856928 | 0.80 | LRRK2 (0.43) | PRKCINTRK1PIK3CADYRK1ALRRK2 | |
| SCHEMBL857272 | 0.79 | LRRK2 (0.43) | PRKCINTRK1PIK3CADYRK1ALRRK2 | |
| SCHEMBL856963 | 0.78 | FYN (0.45) | NTRK1PIK3CADYRK1ALRRK2KIT | |
| SCHEMBL857164 | 0.78 | LRRK2 (0.40) | PRKCINTRK1PIK3CADYRK1ALRRK2 | |
| SCHEMBL859106 | 0.78 | FYN (0.44) | NTRK1PIK3CADYRK1ALRRK2KIT | |
| SCHEMBL858237 | 0.78 | LRRK2 (0.56) | PRKCINTRK1DYRK1ALRRK2FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696920-B1 | COMPOUNDS AND METHODS FOR DEVELOPMENT OF RET MODULATORS | PLEXXIKON INC (US) | 2014-10-29 | — | — | EP | disclosed |