Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 19/20 | 0.78 |
| ▸ | JAK2 | O60674 | 15/20 | 0.78 |
| ▸ | JAK3 | P52333 | 13/20 | 0.78 |
| ▸ | TYK2 | P29597 | 9/20 | 0.78 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12888159 | 1.00 | JAK1 (0.78) | JAK1JAK2JAK3TYK2IRAK4 | |
| SCHEMBL16199901 | 1.00 | JAK1 (0.78) | JAK1JAK2JAK3TYK2IRAK4 | |
| SCHEMBL12876521 | 1.00 | JAK1 (0.78) | JAK1JAK2JAK3TYK2IRAK4 | |
| SCHEMBL12875990 | 1.00 | JAK1 (0.78) | JAK1JAK2JAK3TYK2IRAK4 | |
| SCHEMBL12875962 | 0.91 | JAK1 (0.80) | JAK1JAK2JAK3TYK2 | |
| Hydrochloric Acid SCHEMBL14875678 | 0.91 | JAK1 (0.80) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL1154573 | 0.90 | JAK1 (0.81) | JAK1JAK2JAK3TYK2 | |
| Hydrochloric Acid SCHEMBL1154913 | 0.90 | JAK1 (0.78) | JAK1JAK2JAK3TYK2 | |
| Hydrochloric Acid SCHEMBL1154911 | 0.90 | JAK1 (0.78) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL1154576 | 0.90 | JAK1 (0.81) | JAK1JAK2JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966200-B1 | HETEROCYCLIC JANUS KINASE 3 INHIBITORS | ASTELLAS PHARMA INC (JP) | 2014-10-29 | — | — | EP | disclosed |