Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 1.00 |
| ▸ | JAK3 | P52333 | 19/20 | 1.00 |
| ▸ | JAK1 | P23458 | 16/20 | 1.00 |
| ▸ | TYK2 | P29597 | 5/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12888258 | 1.00 | JAK2 (1.00) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL12904175 | 1.00 | JAK2 (1.00) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL12876084 | 0.89 | JAK1 (0.80) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL12888278 | 0.88 | JAK2 (0.80) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL12876335 | 0.88 | JAK2 (0.80) | JAK2JAK3JAK1TYK2 | |
| Peficitinib SCHEMBL24212690 | 0.87 | JAK3 (1.00) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL12876287 | 0.87 | JAK2 (0.81) | JAK2JAK3JAK1TYK2 | |
| Peficitinib SCHEMBL9990240 | 0.87 | JAK3 (1.00) | JAK2JAK3JAK1TYK2 | |
| Peficitinib SCHEMBL9990248 | 0.87 | JAK3 (1.00) | JAK2JAK3JAK1TYK2 | |
| Peficitinib SCHEMBL22404910 | 0.87 | JAK3 (1.00) | JAK2JAK3JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966200-B1 | HETEROCYCLIC JANUS KINASE 3 INHIBITORS | ASTELLAS PHARMA INC (JP) | 2014-10-29 | — | — | EP | disclosed |