Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Peficitinib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 known ✓ | P52333 | 18/20 | 1.00 |
| ▸ | JAK2 known ✓ | O60674 | 17/20 | 1.00 |
| ▸ | JAK1 known ✓ | P23458 | 16/20 | 1.00 |
| ▸ | TYK2 known ✓ | P29597 | 6/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Peficitinib SCHEMBL9990240 | 1.00 | JAK3 (1.00) | JAK3JAK2JAK1TYK2 | |
| Peficitinib SCHEMBL16199902 | 1.00 | JAK3 (1.00) | JAK3JAK2JAK1TYK2 | |
| Peficitinib SCHEMBL1155034 | 1.00 | JAK3 (1.00) | JAK3JAK2JAK1TYK2 | |
| Peficitinib SCHEMBL1154418 | 1.00 | JAK3 (1.00) | JAK3JAK2JAK1TYK2 | |
| Peficitinib SCHEMBL17645135 | 1.00 | JAK3 (1.00) | JAK3JAK2JAK1TYK2 | |
| Peficitinib SCHEMBL24212690 | 1.00 | JAK3 (1.00) | JAK3JAK2JAK1TYK2 | |
| Peficitinib SCHEMBL9990248 | 1.00 | JAK3 (1.00) | JAK3JAK2JAK1TYK2 | |
| Peficitinib SCHEMBL1154421 | 1.00 | JAK3 (1.00) | JAK3JAK2JAK1TYK2 | |
| Peficitinib SCHEMBL22404910 | 1.00 | JAK3 (1.00) | JAK3JAK2JAK1TYK2 | |
| Peficitinib SCHEMBL4447032 | 1.00 | JAK3 (1.00) | JAK3JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966200-B1 | HETEROCYCLIC JANUS KINASE 3 INHIBITORS | ASTELLAS PHARMA INC (JP) | 2014-10-29 | — | — | EP | disclosed |