Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 4/20 | 0.44 |
| ▸ | METAP2 | P50579 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | CCR1 | P32246 | 2/20 | 0.43 |
| ▸ | CCR5 | P51681 | 2/20 | 0.43 |
| ▸ | CCR8 | P51685 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.43 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13162523 | 0.81 | LRRK2 (0.53) | METAP1METAP2CCR1CCR5CCR8 | |
| SCHEMBL13184351 | 0.79 | KDM4E (0.43) | METAP1METAP2CCR1CCR5CCR8 | |
| SCHEMBL13184341 | 0.78 | MAPK14 (0.42) | — | |
| SCHEMBL10513200 | 0.77 | CCR1 (0.46) | METAP1METAP2KMT2AOPRK1CCR1 | |
| SCHEMBL10922758 | 0.76 | KDM4E (0.41) | METAP1METAP2CCR1CCR5CCR8 | |
| SCHEMBL3464293 | 0.76 | TDP1 (0.42) | METAP1METAP2KMT2ACCR1CCR5 | |
| SCHEMBL16200169 | 0.75 | POLB (0.42) | METAP1METAP2KMT2AOPRK1CCR1 | |
| SCHEMBL28361909 | 0.74 | KDM4E (0.54) | METAP1METAP2KMT2AOPRK1CCR1 | |
| SCHEMBL10515617 | 0.73 | AKT2 (0.58) | METAP1METAP2KMT2ACCR1CCR5 | |
| SCHEMBL30230891 | 0.73 | AKT2 (0.58) | METAP1METAP2KMT2ACCR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |