Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | GCGR | P47871 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13683181 | 0.81 | PDE4D (0.42) | PDE4DPDE10APOLBDYRK1AHTT | |
| SCHEMBL16200196 | 0.81 | PDE4D (0.42) | PDE4DPDE10ADYRK1AHTTMAPK13 | |
| SCHEMBL16200174 | 0.77 | DYRK1A (0.41) | PDE4DPDE10APOLBDYRK1AHTT | |
| SCHEMBL12441704 | 0.71 | DYRK1A (0.53) | DYRK1AMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL13184312 | 0.70 | BRD4 (0.35) | PDE10APOLBHTTMAPK14KMT2A | |
| SCHEMBL12073250 | 0.70 | PDE4D (0.35) | PDE4DPDE10APOLBDYRK1AHTT | |
| SCHEMBL19412676 | 0.70 | PDE4D (0.49) | PDE4DPDE10ADYRK1AADORA2AMAP4K4 | |
| SCHEMBL1896511 | 0.70 | DYRK1A (0.65) | DYRK1ACLK1UHRF1MAP4K4 | |
| SCHEMBL30308690 | 0.70 | DYRK1A (0.65) | DYRK1ACLK1UHRF1MAP4K4 | |
| SCHEMBL16200245 | 0.69 | HTT (0.46) | PDE4DPDE10APOLBDYRK1AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |