Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 13/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.49 |
| ▸ | ULK1 | O75385 | 1/20 | 0.46 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12562970 | 0.92 | EGFR (0.48) | LRRK2PTK2EGFRALK | |
| SCHEMBL12562893 | 0.91 | PTK2 (0.47) | LRRK2PTK2EGFRALK | |
| SCHEMBL14806704 | 0.91 | LRRK2 (0.49) | LRRK2PTK2EGFRALK | |
| SCHEMBL1943155 | 0.90 | LRRK2 (0.49) | LRRK2PTK2EGFRALK | |
| SCHEMBL14823152 | 0.89 | PTK2 (0.51) | LRRK2PTK2ULK1ULK2EGFR | |
| SCHEMBL14806703 | 0.88 | PTK2 (0.58) | LRRK2PTK2 | |
| SCHEMBL14806667 | 0.87 | PTK2 (0.46) | LRRK2PTK2ULK1ULK2EGFR | |
| SCHEMBL12562692 | 0.87 | EGFR (0.48) | LRRK2PTK2EGFRALK | |
| SCHEMBL1943345 | 0.87 | ALK (0.60) | PTK2EGFRALK | |
| SCHEMBL1941994 | 0.86 | EGFR (0.65) | PTK2EGFRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435411-B1 | 2,4-DIAMINOPYRIMIDINES FOR THE TREATMENT OF DISEASES CHARACTERISED BY EXCESSIVE OR ABNORMAL CELL PROLIFERATION | BOEHRINGER INGELHEIM INT (DE) | 2014-10-29 | — | — | EP | disclosed |