Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTBK1 | Q5TCY1 | 12/20 | 0.58 |
| ▸ | CHUK | O15111 | 5/20 | 0.51 |
| ▸ | MAP3K14 | Q99558 | 3/20 | 0.49 |
| ▸ | PIKFYVE | Q9Y2I7 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16205457 | 0.89 | CHUK (0.63) | TTBK1CHUKMAP3K14PIKFYVE | |
| SCHEMBL16205645 | 0.89 | TTBK1 (0.58) | TTBK1CHUKMAP3K14PIKFYVE | |
| SCHEMBL16205426 | 0.88 | CHUK (0.64) | TTBK1CHUKMAP3K14PIKFYVE | |
| SCHEMBL16205449 | 0.87 | TTBK1 (0.55) | TTBK1CHUKMAP3K14PIKFYVE | |
| SCHEMBL16205428 | 0.85 | TTBK1 (0.54) | TTBK1CHUKMAP3K14PIKFYVE | |
| SCHEMBL16205427 | 0.85 | TTBK1 (0.54) | TTBK1CHUKMAP3K14PIKFYVE | |
| SCHEMBL16205707 | 0.83 | TTBK1 (0.51) | TTBK1CHUKMAP3K14PIKFYVE | |
| SCHEMBL16205479 | 0.83 | TTBK1 (0.68) | TTBK1CHUKPIKFYVE | |
| SCHEMBL16205478 | 0.81 | TTBK1 (0.62) | TTBK1CHUKPIKFYVE | |
| SCHEMBL16205486 | 0.81 | TTBK1 (0.62) | TTBK1CHUKPIKFYVE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9643964-B2 | 3-(2-aminopyrimidin-4-yl)-5-(3-hydroxypropynyl)-1H-pyrrolo[2,3-C]pyridine derivatives as NIK inhibitors for the treatment of cancer | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-09 | — | — | US | disclosed |
| WO-2014174021-A1 | 3-(2-AMINOPYRIMIDIN-4-YL)-5-(3-HYDROXYPROPYNYL)-1H-PYRROLO[2,3-C]PYRIDINE DERIVATIVES AS NIK INHIBITORS FOR THE TREATMENT OF CANCER | JANSSEN PHARMACEUTICA NV (BE) | 2014-10-30 | — | — | WO | disclosed |