Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.84 |
| ▸ | EML4 | Q9HC35 | 4/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.52 |
| ▸ | RET | P07949 | 2/20 | 0.52 |
| ▸ | ROS1 | P08922 | 2/20 | 0.52 |
| ▸ | FLT3 | P36888 | 2/20 | 0.52 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16206994 | 0.92 | EGFR (0.84) | EGFREML4ALKRETROS1 | |
| SCHEMBL16196020 | 0.92 | EGFR (1.00) | EGFREML4ALKRETROS1 | |
| SCHEMBL16207132 | 0.92 | EGFR (0.83) | EGFREML4ALKRETROS1 | |
| SCHEMBL16207129 | 0.90 | EGFR (0.77) | EGFRMAP3K7MAPK1MAP2K1 | |
| SCHEMBL16207157 | 0.90 | EGFR (0.80) | EGFREML4ALKRETROS1 | |
| SCHEMBL16207329 | 0.89 | EGFR (0.84) | EGFREML4ALKRETROS1 | |
| SCHEMBL16195522 | 0.89 | EGFR (1.00) | EGFR | |
| SCHEMBL16206921 | 0.88 | EGFR (0.65) | EGFREML4ALKRETROS1 | |
| SCHEMBL16207152 | 0.88 | EGFR (0.80) | EGFREML4ALKRETROS1 | |
| SCHEMBL16207000 | 0.87 | EGFR (0.87) | EGFREML4ALKFLT3MAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9085540-B2 | Pyrazinecarboxamide compound | ASTELLAS PHARMA INC. (JP) | 2015-07-21 | — | — | US | disclosed |
| US-9085540-B2 | Pyrazinecarboxamide compound | ASTELLAS PHARMA INC. (JP) | 2015-07-21 | — | — | US | disclosed |
| US-20140323463-A1 | PYRAZINECARBOXAMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2014-10-30 | — | — | US | disclosed |
| US-20140323463-A1 | PYRAZINECARBOXAMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2014-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140323463-A1 | PYRAZINECARBOXAMIDE COMPOUND | EGFR, ERBB2, ALK | EGFR 1/4885EML4 158/4885ALK 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.