Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 1.00 |
| ▸ | MTOR | P42345 | 11/20 | 1.00 |
| ▸ | AKT1 | P31749 | 7/20 | 1.00 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.71 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.71 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.71 |
| ▸ | PRKDC | P78527 | 1/20 | 0.71 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1621105 | 0.89 | PIK3CA (0.79) | PIK3CAMTORAKT1PIK3CDPIK3CB | |
| SCHEMBL1620258 | 0.89 | PIK3CA (0.79) | PIK3CAMTORAKT1PIK3CDPIK3CB | |
| SCHEMBL1622169 | 0.87 | PIK3CA (0.82) | PIK3CAMTORAKT1PIK3CDPIK3CB | |
| SCHEMBL1621916 | 0.87 | AKT1 (0.77) | PIK3CAMTORAKT1PIK3CDPIK3CB | |
| SCHEMBL1621813 | 0.87 | AKT1 (0.77) | PIK3CAMTORAKT1PIK3CDPIK3CB | |
| SCHEMBL1619972 | 0.86 | AKT1 (0.75) | PIK3CAMTORAKT1PIK3CDPIK3CB | |
| SCHEMBL3638738 | 0.85 | AKT1 (0.73) | PIK3CAMTORAKT1PIK3CDPIK3CB | |
| SCHEMBL1621723 | 0.84 | AKT1 (0.72) | PIK3CAMTORAKT1PIK3CDPIK3CB | |
| SCHEMBL1621328 | 0.83 | AKT1 (1.00) | PIK3CAMTORAKT1PIK3CDPIK3CB | |
| SCHEMBL1621416 | 0.83 | AKT1 (0.71) | PIK3CAMTORAKT1PIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183232-B1 | PI3 KINASE MODULATORS AND METHODS OF USE | AMGEN INC (US) | 2013-03-06 | — | — | EP | claimed |
| EP-2183232-A2 | PI3 KINASE MODULATORS AND METHODS OF USE | Amgen, Inc (US) | 2010-05-12 | — | — | EP | claimed |
| US-20090054405-A1 | PI3 kinase modulators and methods of use | AMGEN INC. (US) | 2009-02-26 | — | — | US | claimed |
| WO-2009017822-A2 | PI3 KINASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2009-02-05 | — | — | WO | claimed |
| EP-2183232-B1 | PI3 KINASE MODULATORS AND METHODS OF USE | AMGEN INC (US) | 2013-03-06 | — | — | EP | disclosed |
| US-7928140-B2 | Benzothiazole PI3 kinase modulators for cancer treatment | AMGEN INC. (US) | 2011-04-19 | — | — | US | disclosed |
| US-7928140-B2 | Benzothiazole PI3 kinase modulators for cancer treatment | AMGEN INC. (US) | 2011-04-19 | — | — | US | disclosed |
| US-7928140-B2 | Benzothiazole PI3 kinase modulators for cancer treatment | AMGEN INC. (US) | 2011-04-19 | — | — | US | disclosed |
| EP-2183232-A2 | PI3 KINASE MODULATORS AND METHODS OF USE | Amgen, Inc (US) | 2010-05-12 | — | — | EP | disclosed |
| US-20090054405-A1 | PI3 kinase modulators and methods of use | AMGEN INC. (US) | 2009-02-26 | — | — | US | disclosed |
| US-20090054405-A1 | PI3 kinase modulators and methods of use | AMGEN INC. (US) | 2009-02-26 | — | — | US | disclosed |
| US-20090054405-A1 | PI3 kinase modulators and methods of use | AMGEN INC. (US) | 2009-02-26 | — | — | US | disclosed |
| WO-2009017822-A2 | PI3 KINASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2009-02-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054405-A1 | PI3 kinase modulators and methods of use | PIK3CA, PIK3C2A, PIK3C2B | PIK3CA 1/4885MTOR 37/4885AKT1 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.