Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 19/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16213721 | 0.88 | ACACB (0.59) | ACACB | |
| SCHEMBL16481368 | 0.88 | ACACB (0.59) | ACACB | |
| SCHEMBL18176134 | 0.86 | ACACB (0.54) | ACACB | |
| SCHEMBL16187531 | 0.86 | ACACB (0.54) | ACACB | |
| SCHEMBL16214228 | 0.85 | ACACB (0.54) | ACACB | |
| SCHEMBL16187532 | 0.84 | SMN1; SMN2 (0.51) | ACACBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15918506 | 0.84 | SMN1; SMN2 (0.51) | ACACBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11399733 | 0.84 | SMN1; SMN2 (0.68) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15634450 | 0.84 | ACACB (0.64) | ACACB | |
| SCHEMBL15901017 | 0.84 | ACACB (0.59) | ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9169205-B2 | Pyrrolidine derivatives, pharmaceutical compositions and uses thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-10-27 | — | — | US | disclosed |
| US-9169205-B2 | Pyrrolidine derivatives, pharmaceutical compositions and uses thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-10-27 | — | — | US | disclosed |
| US-8877741-B2 | Pyrrolidine derivatives, pharmaceutical compositions and uses thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-11-04 | — | — | US | disclosed |
| US-8877741-B2 | Pyrrolidine derivatives, pharmaceutical compositions and uses thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-11-04 | — | — | US | disclosed |