Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 20/20 | 0.68 |
| ▸ | CTSK | P43235 | 6/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16070953 | 0.85 | CTSC (0.62) | CTSCCTSK | |
| SCHEMBL14821954 | 0.84 | CTSC (0.61) | CTSCCTSK | |
| SCHEMBL15083922 | 0.82 | CTSC (0.58) | CTSCCTSK | |
| SCHEMBL19187685 | 0.82 | CTSC (0.58) | CTSCCTSK | |
| SCHEMBL16045001 | 0.81 | CTSC (1.00) | CTSCCTSK | |
| SCHEMBL16478367 | 0.81 | CTSC (0.71) | CTSCCTSK | |
| SCHEMBL16622364 | 0.80 | CTSC (1.00) | CTSCCTSK | |
| SCHEMBL15084142 | 0.80 | CTSC (0.73) | CTSCCTSK | |
| SCHEMBL16071097 | 0.79 | CTSC (0.62) | CTSCCTSK | |
| SCHEMBL15081724 | 0.78 | CTSC (0.62) | CTSCCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8877775-B2 | Substituted 2-aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-11-04 | — | — | US | disclosed |