Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 4/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | HTR2B | P41595 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | DRD1 | P21728 | 3/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.33 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.33 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL162152 | 1.00 | TAAR1 (0.40) | TAAR1HTR2CHTR2AHTR2BTSHR | |
| Glutamic Acid SCHEMBL158772 | 0.89 | GRM8 (0.39) | TAAR1HTR2CHTR2AHTR2BTSHR | |
| Glutamic Acid SCHEMBL161669 | 0.89 | GRM8 (0.39) | TAAR1HTR2CHTR2AHTR2BTSHR | |
| Succinic Acid SCHEMBL161276 | 0.84 | TAAR1 (0.47) | TAAR1HTR2CHTR2AHTR2BTSHR | |
| Malonic Acid SCHEMBL160930 | 0.84 | TAAR1 (0.47) | TAAR1HTR2CHTR2AHTR2BTSHR | |
| Glycolic Acid SCHEMBL162065 | 0.84 | TAAR1 (0.47) | TAAR1HTR2CHTR2AHTR2BTSHR | |
| Adipic Acid SCHEMBL174687 | 0.82 | HTR2C (0.48) | TAAR1HTR2CHTR2AHTR2BTSHR | |
| Adipic Acid SCHEMBL161399 | 0.82 | HTR2C (0.48) | TAAR1HTR2CHTR2AHTR2BTSHR | |
| SCHEMBL163850 | 0.81 | HTR2C (0.57) | TAAR1HTR2CHTR2AHTR2BSLC6A2 | |
| SCHEMBL162669 | 0.81 | HTR2C (0.57) | TAAR1HTR2CHTR2AHTR2BSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012030953-A1 | 5-HT2C RECEPTOR AGONISTS IN THE TREATMENT OF DISORDERS AMELIORATED BY REDUCTION OF NOREPINEPHRINE LEVEL | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |