Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.65 |
| ▸ | ERBB2 | P04626 | 11/20 | 0.65 |
| ▸ | ERBB4 | Q15303 | 5/20 | 0.55 |
| ▸ | SRC | P12931 | 3/20 | 0.55 |
| ▸ | ABL1 | P00519 | 2/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.55 |
| ▸ | FLT3 | P36888 | 2/20 | 0.55 |
| ▸ | KIT | P10721 | 2/20 | 0.52 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.52 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.52 |
| ▸ | CIT | O14578 | 1/20 | 0.52 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.52 |
| ▸ | GAK | O14976 | 1/20 | 0.52 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.52 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.52 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.52 |
| ▸ | STK17B | O94768 | 1/20 | 0.52 |
| ▸ | STK10 | O94804 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16219760 | 1.00 | EGFR (0.65) | EGFRERBB2ERBB4SRCABL1 | |
| SCHEMBL16219786 | 0.91 | EGFR (0.68) | EGFRERBB2ERBB4SRCABL1 | |
| SCHEMBL16219790 | 0.91 | EGFR (0.68) | EGFRERBB2ERBB4SRCABL1 | |
| SCHEMBL16219783 | 0.91 | EGFR (0.76) | EGFRERBB2ERBB4SRCABL1 | |
| SCHEMBL16219779 | 0.91 | EGFR (0.76) | EGFRERBB2ERBB4SRCABL1 | |
| SCHEMBL16219768 | 0.91 | EGFR (0.63) | EGFRERBB2ERBB4SRCABL1 | |
| SCHEMBL16219764 | 0.91 | EGFR (0.63) | EGFRERBB2ERBB4SRCABL1 | |
| SCHEMBL16219863 | 0.90 | EGFR (0.67) | EGFRERBB2ERBB4SRCGAK | |
| SCHEMBL16219865 | 0.90 | EGFR (0.69) | EGFRERBB2ERBB4SRCABL1 | |
| SCHEMBL16219854 | 0.90 | EGFR (0.69) | EGFRERBB2ERBB4SRCABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014177038-A1 | AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2014-11-06 | — | — | WO | disclosed |