Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.75 |
| ▸ | ERBB2 | P04626 | 16/20 | 0.75 |
| ▸ | ERBB4 | Q15303 | 7/20 | 0.75 |
| ▸ | GAK | O14976 | 2/20 | 0.72 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.72 |
| ▸ | LCK | P06239 | 2/20 | 0.72 |
| ▸ | SRC | P12931 | 2/20 | 0.72 |
| ▸ | MC3R | P41968 | 2/20 | 0.72 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.72 |
| ▸ | JAK3 | P52333 | 2/20 | 0.72 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.72 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.72 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.72 |
| ▸ | DRD2 | P14416 | 1/20 | 0.72 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.72 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.72 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.72 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.72 |
| ▸ | CIT | O14578 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16219961 | 0.92 | EGFR (0.81) | EGFRERBB2ERBB4GAKRIPK2 | |
| SCHEMBL16219810 | 0.92 | EGFR (0.81) | EGFRERBB2ERBB4GAKRIPK2 | |
| SCHEMBL12936072 | 0.90 | EGFR (0.78) | EGFRERBB2ERBB4GAKRIPK2 | |
| SCHEMBL16219911 | 0.89 | EGFR (0.74) | EGFRERBB2ERBB4GAKRIPK2 | |
| SCHEMBL16219871 | 0.87 | EGFR (0.75) | EGFRERBB2ERBB4GAKRIPK2 | |
| SCHEMBL16219926 | 0.87 | EGFR (0.75) | EGFRERBB2ERBB4GAKRIPK2 | |
| SCHEMBL17498557 | 0.87 | EGFR (0.75) | EGFRERBB2ERBB4GAKRIPK2 | |
| SCHEMBL22277127 | 0.87 | EGFR (0.88) | EGFRERBB2ERBB4GAKRIPK2 | |
| SCHEMBL30115324 | 0.87 | EGFR (0.88) | EGFRERBB2ERBB4GAKRIPK2 | |
| SCHEMBL16219803 | 0.86 | EGFR (0.81) | EGFRERBB2ERBB4GAKRIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556191-B2 | Aminoquinazoline derivatives and their salts and methods of use thereof | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2017-01-31 | — | — | US | disclosed |
| WO-2014177038-A1 | AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2014-11-06 | — | — | WO | disclosed |